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KMID : 0644120080210020125
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Journal of Oriental Gynecology
2008 Volume.21 No. 2 p.125 ~ p.151
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The Effect of Eungapbang-gagam on Thrombus Disease Related Factors and Oxidative Stress
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Lee Su-Jeong
Kim Song-Baeg
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Abstract
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Purpose: In this study, we investigated the anti-thrombotic efficacy of "Eungapbang-gagam(EGB)" currently used in clinical treatment of PID.
Methods: We studied inhibitory effect of platelet cohesion, suppressive effect of GPIIb/IIIa activity, inhibitory effect of TXB2 and PGE2 biosynthesis, and oxidative damage suppression effects of "EGB" in vitro. Also, suppression of
pulmonary embolism and changes of related factors in dextran coagulation condition model were studied in vivo.
Results: In this study, EGB extract showed dose-dependent inhibitory effect on platelet coagulation induced by ADP, epinephrine, collagen, arachidonic acid. Also it showed dose-dependent inhibition effect on GPIIb/IIIa activities
compared to the control group. EGB extract significantly suppressed the decrease of speed of bloodstream caused by blood coagulation in dextran coagulation condition model and increased the number of platelets and amount of fibrinogen,
and decreased the APTT in dextran coagulation condition model compared to the control group. EGB extract showed dose-dependent decrease of oxidative damages caused by DPPH and superoxide anion radicals, whereas dose-dependent increase of superoxide dismutase like activity was observed compared to the control group.
Conclusion: We confirmed the anti-thrombosis and anti-oxidative efficacy of "Eungapbang-gagam". Various clinical applications of "Eungapbang-gagam" as well as use of data for the construction of EBM is anticipated.
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KEYWORD
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Eungapbang-gagam(EGB), platelet aggregation, anti-thrombosis, anti-oxidative, Herbal medicine
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